Endocrine Abstracts

Objectives: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a validated and widely used tool for thyroid nodules triage. Studies reporting on the frequency of each Bethesda category are scarce, and there are wide discrepancies in the reported results between the various centers. Our aim was to register all cytological reports of the thyroid fine needle aspiration biopsies (FNAB) reviewed in the Cytology Department of a tertiary hospital during a calendar ye...

Purpose: Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-I) are currently the principal biomarkers used to assess disease activity in acromegaly and any discrepancy between them renders interpretation of results inconclusive. The purpose of this study was to assess the frequency of discrepant results and identify parameters that might affect the emergence of this phenomenon.Methods: A systematic review of Medline and Scopus was performed (1987&...

Objective: Somatic mutations in the GNAS1 gene, which encodes the alpha-subunit of G stimulatory proteins (gsp), are frequently detected in somatotroph pituitary tumors and have been associated to specific clinical-smaller and less invasive tumors occurring in older patients- and histopathological-densely granulated adenomas- characteristics. However, the question whether the presence of a somatic gsp mutation affects the response to somatostatin analogue treatment remains unr...